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Telomerase

Telomerase Products

  • All (11)
  • Telomerase Inhibitors (8)
  • Telomerase Activators (3)
  • New Telomerase Products
Catalog No. Product Name Information Product Use Citations Product Validations
S2250 EGCG ((-)-Epigallocatechin Gallate) EGCG ((-)-Epigallocatechin Gallate) is the main catechin extraction of green tea that inhibits telomerase and DNA methyltransferase. EGCG blocks the activation of EGF receptors and HER-2 receptors. ECGG inhibits fatty acid synthase and glutamate dehydrogenase activity.
Journal of Functional Foods, 2024, 105977
Cell Rep Med, 2023, 4(5):101026
Transl Oncol, 2023, 35:101712
S1186 BIBR 1532 BIBR 1532 is a potent, selective, non-competitive telomerase inhibitor with IC50 of 100 nM in a cell-free assay. No inhibition of DNA and RNA polymerases, including HIV reverse transcriptase are observed at concentrations vastly exceeding the IC50 for telomerase. BIBR 1532 induces apoptosis in cancer cells.
Biogerontology, 2024, 10.1007/s10522-024-10094-x
JCI Insight, 2023, 10.1172/jci.insight.170320
Cancers (Basel), 2023, 15(10)2673
S1319 Costunolide Costunolide (NSC 106404), a natural sesquiterpene compound with multiple biological activities; inhibits FPTase with IC50 of 20 μM, also inhibits telomerase with IC50 of 65-90 μM.
J Tradit Complement Med, 2023, 13(4):345-357
Pathol Res Pract, 2022, 236:153966
Front Plant Sci, 2021, 12:699068
S8118 RHPS 4 methosulfate RHPS4 (NSC714187) is a potent inhibitor of Telomerase at submicromolar.
Cancers (Basel), 2022, 14(11)2624
J Am Chem Soc, 2021, 143(49):20779-20791
Elife, 2021, 10e65184
S3894 Cycloastragenol Cycloastragenol (CAG, TA-65, Cyclogalegigenin, Astramembrangenin) is a saponin comprising a group of oil glucosides naturally present in a number of plants. It is a potent telomerase activator in neuronal cells.
Cancer Sci, 2020, 111(8):2789-2802
S3273 Hypericin Hypericin (Hyp, HY) is a naturally occurring substance found in the common St. John's Wort (Hypericum species) with antidepressive, antineoplastic and antiviral (human immunodeficiency and hepatitis C virus) activities. Hypericin has inhibitory effects on MAO (monoaminoxidase), PKC (protein kinase C), dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450).
Eur J Pharmacol, 2021, 900:174071
E4660New TAC(TERT activator compound) TAC(TERT activator compound) is an activator of TERT, that upregulates TERT transcription via the MEK/ERK/AP-1 cascade. It enhances telomere synthesis, reduces aging markers, inflammation, and senescence, and preserves brain function, highlighting TERT's potential in combating aging and related diseases.
S4981 Cyclogalegenol Cyclogalegenol (Astramembrangenin, Cyclosieversigenin), the aglycone derivative of astragaloside A, is found in various species of Astragalus and may activate telomerase.
E1302New Braco-19 trihydrochloride Braco-19 trihydrochloride(BRAC-O19, BRACO19 3HCl) is a G-quadruplex-stabilizing agent and an inhibitor of telomere/telomerase. It establishes antiviral activity against HIV-1 and anticancer effects by inhibiting telomerase capping and catalytic functions.
E4620New L-778123 hydrochloride L-778123 hydrochloride is a potent dual inhibitor of farnesyl protein transferase (FPTase) with an IC50 of 2 nM and geranylgeranyl protein transferase I (GGPTase-I) with an IC50 of 98 nM. It also displays promising anti-leukemia activity.
E1739New MST-312 MST-312(Telomerase Inhibitor IX) is an inhibitor of telomerase. MST-312 is a chemically modified derivative of green tea epigallocatechin gallate (EGCG). MST-312 exhibits high chemical stability, lowers the effective dose in the induction of telomere shortening, and lowers drug resistance. MST-312 can be used for the research of cancer. MST-312 can also be used as a promising strategy in the treatment of multiple myeloma (MM).
S2250 EGCG ((-)-Epigallocatechin Gallate) EGCG ((-)-Epigallocatechin Gallate) is the main catechin extraction of green tea that inhibits telomerase and DNA methyltransferase. EGCG blocks the activation of EGF receptors and HER-2 receptors. ECGG inhibits fatty acid synthase and glutamate dehydrogenase activity.
Journal of Functional Foods, 2024, 105977
Cell Rep Med, 2023, 4(5):101026
Transl Oncol, 2023, 35:101712
S1186 BIBR 1532 BIBR 1532 is a potent, selective, non-competitive telomerase inhibitor with IC50 of 100 nM in a cell-free assay. No inhibition of DNA and RNA polymerases, including HIV reverse transcriptase are observed at concentrations vastly exceeding the IC50 for telomerase. BIBR 1532 induces apoptosis in cancer cells.
Biogerontology, 2024, 10.1007/s10522-024-10094-x
JCI Insight, 2023, 10.1172/jci.insight.170320
Cancers (Basel), 2023, 15(10)2673
S1319 Costunolide Costunolide (NSC 106404), a natural sesquiterpene compound with multiple biological activities; inhibits FPTase with IC50 of 20 μM, also inhibits telomerase with IC50 of 65-90 μM.
J Tradit Complement Med, 2023, 13(4):345-357
Pathol Res Pract, 2022, 236:153966
Front Plant Sci, 2021, 12:699068
S8118 RHPS 4 methosulfate RHPS4 (NSC714187) is a potent inhibitor of Telomerase at submicromolar.
Cancers (Basel), 2022, 14(11)2624
J Am Chem Soc, 2021, 143(49):20779-20791
Elife, 2021, 10e65184
S3273 Hypericin Hypericin (Hyp, HY) is a naturally occurring substance found in the common St. John's Wort (Hypericum species) with antidepressive, antineoplastic and antiviral (human immunodeficiency and hepatitis C virus) activities. Hypericin has inhibitory effects on MAO (monoaminoxidase), PKC (protein kinase C), dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450).
Eur J Pharmacol, 2021, 900:174071
E1302New Braco-19 trihydrochloride Braco-19 trihydrochloride(BRAC-O19, BRACO19 3HCl) is a G-quadruplex-stabilizing agent and an inhibitor of telomere/telomerase. It establishes antiviral activity against HIV-1 and anticancer effects by inhibiting telomerase capping and catalytic functions.
E4620New L-778123 hydrochloride L-778123 hydrochloride is a potent dual inhibitor of farnesyl protein transferase (FPTase) with an IC50 of 2 nM and geranylgeranyl protein transferase I (GGPTase-I) with an IC50 of 98 nM. It also displays promising anti-leukemia activity.
E1739New MST-312 MST-312(Telomerase Inhibitor IX) is an inhibitor of telomerase. MST-312 is a chemically modified derivative of green tea epigallocatechin gallate (EGCG). MST-312 exhibits high chemical stability, lowers the effective dose in the induction of telomere shortening, and lowers drug resistance. MST-312 can be used for the research of cancer. MST-312 can also be used as a promising strategy in the treatment of multiple myeloma (MM).
S3894 Cycloastragenol Cycloastragenol (CAG, TA-65, Cyclogalegigenin, Astramembrangenin) is a saponin comprising a group of oil glucosides naturally present in a number of plants. It is a potent telomerase activator in neuronal cells.
Cancer Sci, 2020, 111(8):2789-2802
E4660New TAC(TERT activator compound) TAC(TERT activator compound) is an activator of TERT, that upregulates TERT transcription via the MEK/ERK/AP-1 cascade. It enhances telomere synthesis, reduces aging markers, inflammation, and senescence, and preserves brain function, highlighting TERT's potential in combating aging and related diseases.
S4981 Cyclogalegenol Cyclogalegenol (Astramembrangenin, Cyclosieversigenin), the aglycone derivative of astragaloside A, is found in various species of Astragalus and may activate telomerase.
E4660New TAC(TERT activator compound) TAC(TERT activator compound) is an activator of TERT, that upregulates TERT transcription via the MEK/ERK/AP-1 cascade. It enhances telomere synthesis, reduces aging markers, inflammation, and senescence, and preserves brain function, highlighting TERT's potential in combating aging and related diseases.
E1302New Braco-19 trihydrochloride Braco-19 trihydrochloride(BRAC-O19, BRACO19 3HCl) is a G-quadruplex-stabilizing agent and an inhibitor of telomere/telomerase. It establishes antiviral activity against HIV-1 and anticancer effects by inhibiting telomerase capping and catalytic functions.
E4620New L-778123 hydrochloride L-778123 hydrochloride is a potent dual inhibitor of farnesyl protein transferase (FPTase) with an IC50 of 2 nM and geranylgeranyl protein transferase I (GGPTase-I) with an IC50 of 98 nM. It also displays promising anti-leukemia activity.
E1739New MST-312 MST-312(Telomerase Inhibitor IX) is an inhibitor of telomerase. MST-312 is a chemically modified derivative of green tea epigallocatechin gallate (EGCG). MST-312 exhibits high chemical stability, lowers the effective dose in the induction of telomere shortening, and lowers drug resistance. MST-312 can be used for the research of cancer. MST-312 can also be used as a promising strategy in the treatment of multiple myeloma (MM).

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Tags: Telomerase inhibitor|Telomerase agonist|Telomerase activator|Telomerase inducer|Telomerase antagonist|Telomerase signaling pathway|Telomerase assay kit