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Protein Degradation

Molecular Glue & PROTAC

Molecular Glue: Avadomide; Iberdomide; BI-3802; Pomalidomide; Mezigdomide; Indisulam; E7820; CC-99282; Thalidomide; Tasisulam; (R)-CR8 trihydrochloride; Sodium 2-(1H-indol-3-yl)acetate; Lenalidomide; Cyclosporin A; dCeMM1

PROTAC: Gefitinib-based PROTAC 3; MS4078; dBET57; MT-802; dBET1; ARV-825; ARV-771; dBET6; A1874; GMB-475; DT2216; THAL-SNS-032; UNC6852; PROTAC SGK3 degrader-1; GSK215

ADC

Trastuzumab deruxtecan

Sacituzumab govitecan

Trastuzumab Emtansine（T-DM1）

Patritumab deruxtecan

Vorsetuzumab mafodotin

Clivatuzumab-MMAE

Indusatumab vedotin

Lifastuzumab vedotin

Anetumab ravtansine

Polatuzumab vedotin-piiq

Zilovertamab vedotin

Farletuzumab-MMAE

Iladatuzumab vedotin

Pinatuzumab vedotin

Sirtratumab vedotin

Codrituzumab-MMAE

Tusamitamab ravtansine

Serclutamab talirine

Cantuzumab ravtansine

Ozuriftamab vedotin

Sofituzumab vedotin

Laprituximab emtansine

Enapotamab vedotin

Praluzatamab ravtansine

Depatuxizumab mafodotin

Polyubiquitination Modification

Ubiquitin-Protein Ligase: Lenalidomide; Pomalidomide; Thalidomide; Nutlin-3; Serdemetan

Ubiquitin Conjugating Enzyme: NSC697923; NAcM-OPT

Ubiquitin Activating Enzyme: Pevonedistat; TAK-243; PYR-41; ML792; COH000

DUB: BAY 11-7082; PR-619; P5091; Degrasyn; Spautin-1; P22077

SUMO: 2-D08; Subasumstat; Ginkgolic Acid; momordin-Ic; NSC 632839

VCP/p97: NMS-873; CB-5083; DBeQ; MNS; CB-5339; NPD8733

Proteasomal Degradation

26S-proteasome: MG132; (±)-Shikonin

20S-proteasome: Isoginkgetin; Bortezomib; Ixazomib Citrate; Ixazomib Citrate (MLN9708) Analogue; Marizomib; Delanzomib; ONX-0914; Oprozomib; Celastrol; Epoxomicin; Carfilzomib; VR23

Mitophagy Regulation ^[1]

NAD: Nicotinamide Riboside Chloride; β-Nicotinamide Mononucleotide; Nicotinic Acid; Luteolin

SIRT1/3: Resveratrol; Honokiol; Selisistat; SRT1720 HCl; 3-TYP; SRT2104; SRT2183

USP30: MF-094

p53: Pifithrin-α (PFTα) HBr; (-)-Parthenolide; Metformin HCl; Doxorubicin; Harpagoside

Nrf2: Sulforaphane; Tomatidine Hydrochloride

PINK1: Gemcitabine; 1400W 2HCl

MCL-1: UMI-77; VU661013; AZD5991; S63845; MIK665; A-1210477

Lysosomal Pathway

Protein Transport: Brefeldin A; Sodium Monensin; Exo1

Lysosomal Degradation: Bafilomycin A1; EN6; KM91104; Hydroxychloroquine (HCQ) Sulfate; DC661

Endocytosis Regulation

Dansylcadaverine

Methyl-β-cyclodextrin

Compound Library

Protease Inhibitor Library

Protein-protein Interaction Inhibitor Library

Ubiquitination Compound Library

Autophagy Compound Library