Pancreatic Cancer

Modeling Agent

Drugs Approved

Chemotherapy Regimens

FOLFIRINOX

Calcium Folinate

5-FU

Irinotecan hydrochloride

Oxaliplatin

GEMCITABINE-CISPLATIN

Gemcitabine HCl

Cisplatin

GEMCITABINE-OXALIPLATIN

Gemcitabine HCl

Oxaliplatin

OFF

Oxaliplatin

5-FU

Calcium Folinate

GN

Gemcitabine

Nab-Paclitaxel

NALIRIFOX

Irinotecan

5-FU

Folinic acid

Oxaliplatin

S-1

Tegafur

Gimeracil

Potassium oxonate

mFOLFOX6

Folinic acid

5-FU

Oxaliplatin

ESMO Guidelines Recommendations ^[1]

First-Line Treatment

5-FU

Irinotecan hydrochloride

Oxaliplatin

Nab-Paclitaxel

Folinic acid

Second-Line Treatment

5-FU

Gimeracil

Larotrectinib

Folinic acid

Calcium Folinate

Potassium oxonate

Oxaliplatin

Entrectinib

ICIs

PD-1

Pembrolizumab

Dostarlimab

Cemiplimab

Camrelizumab

Sintilimab

Nivolumab

Serplulimab

Balstilimab

PD-L1

Atezolizumab

Durvalumab

Avelumab

Adebrelimab

Sugemalimab

CALT-4

Nurulimab

Zalifrelimab

Quavonlimab

Ipilimumab

Tremelimumab

Anti-Angiogenesis

VEGF

Bevacizumab

Everolimus

Axitinib

Sorafenib

EGFR

Panitumumab

Nimotuzumab

Demupitamab

PDGFR

Crenolanib

Ripretinib

c-kit

Masitinib

TKIs

Sunitinib

Sorafenib

Pazopanib

Targeted Therapy (A) ^[2]

CLDN18.2

Zolbetuximab

MSLN

Anetumab

Anetumab-MMAE

DNA

Lurbinectedin

Oxaliplatin

STZ

Evofosfamide

KRAS G12D

MRTX1133

KRpep-2d

Tubulin

Nab-Paclitaxel

Paclitaxel

Docetaxel

MUC1

Clivatuzumab

Cantuzumab

Gatipotuzumab

Clivatuzumab-MMAE

TOP1

Irinotecan hydrochloride

Rubitecan

TYMS

Leucovorin (Folinic acid) Calcium Pentahydrate

Gimeracil

Capecitabine

Tegafur

Targeted Therapy (B) ^[2]

EGFR

Panitumumab

Nimotuzumab

Demupitamab

CD40

Giloralimab

Sotigalimab

Selicrelumab

FAK

Defactinib

GSK2256098

Narmafotinib

PF-562271

VS-4718

KRAS G12C

Adagrasib

LY3537982

ARS-853

K-Ras(G12C) inhibitor 12

STAT3

Napabucasin

CD73

Mupadolimab

Oleclumab

Uliledlimab

AB680

LY-3475070

CEACAM5

Tusamitamab

Labetuzumab

Cergutuzumab

Tusamitamab ravtansine

Labetuzumab govitecan

CSCs Marker ^[3]

CD44+CD24+ESA+

Curcumin

CD133

Metformin

CD44

Metformin

Angstrom6

EPCAM

Metformin

ALDH1

Metformin

Triptolide

Sulforaphane

Disulfiram

NCT-501

DCLK1

Licofelone

DCLK1-IN-1

Compound Library