Andrographolide

Catalog No.S2261 Batch:S226104

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Technical Data

Formula

C20H30O5

Molecular Weight 350.45 CAS No. 5508-58-7
Solubility (25°C)* In vitro DMSO 70 mg/mL (199.74 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description Andrographolide is a labdane diterpenoid that is the main bioactive component of the medicinal plant Andrographis paniculata.
Targets
NF-κB [1]

Protocol (from reference)

Selleck's Andrographolide has been cited by 11 publications

Andrographolide Inhibits Corneal Fibroblast to Myofibroblast Differentiation In Vitro [ Biomolecules, 2022, 12(10)1447] PubMed: 36291655
Andrographolide Inhibits Corneal Fibroblast to Myofibroblast DifferentiationIn Vitro [ Biomolecules, 2022, 12(10), 1447] PubMed: None
Andrographolide Inhibits Corneal Fibroblast to Myofibroblast Differentiation In Vitro [ Biomolecules, 2022, 12-101447] PubMed: 36291655
Andrographolide Inhibits ER-Positive Breast Cancer Growth and Enhances Fulvestrant Efficacy via ROS-FOXM1-ER-α Axis [ Front Oncol, 2022, 12:899402] PubMed: 35615146
Endothelial Cell-Derived SO2 Controls Endothelial Cell Inflammation, Smooth Muscle Cell Proliferation, and Collagen Synthesis to Inhibit Hypoxic Pulmonary Vascular Remodelling [ Oxid Med Cell Longev, 2021, 2021:5577634] PubMed: 33953829
Andrographolide Induces Apoptosis in Human Osteosarcoma Cells via the ROS/JNK Pathway [ Int J Oncol, 2020, 56(6):1417-1428] PubMed: 32236589
In vitro benchmarking of NF-κB inhibitors. [ Eur J Pharmacol, 2020, 873:172981] PubMed: 32014486
Visualization of GLUT1 Trafficking in Live Cancer Cells by the Use of a Dual-Fluorescence Reporter [ ACS Omega, 2020, 5(26):15911-15921] PubMed: 32656411
An antiviral drug screening system for enterovirus 71 based on an improved plaque assay: A potential high-throughput method [ J Med Virol, 2019, 91(8):1440-1447] PubMed: 30900754
Andrographolide inhibits inflammatory responses in LPS-stimulated macrophages and murine acute colitis through activating AMPK. [ Biochem Pharmacol, 2019, 170:113646] PubMed: 31545974

RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.