Gamma-secretase is a special protease complex with different subunits which are four hydrophobic proteins within total at least 19 transmembrane domains (TMs). Gamma-secretase establishes proteolytic mechanism through cleaving many substance including aspartic (Presenilin and signal peptide peptidase), serine (rhomboids) and zinc metalloproteases (S2-protease) and so on. One of the most important role of gramme-Secretase is that gramme-Secretase is responsible for the final step in the processing of the amyloid precursor protein (APP), generating the amyloid-beta peptides, which initiate the complex pathological cascade leading to Alzheimer’s disease (AD). Gamma-secretase also plays a key role in Notch signaling pathway.
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