Name: Licochalcone D
Brand: Selleck Chemicals
SKU: S6899
Rating: 5 (1 reviews)

Licochalcone D (Lico D, LCD, LD), a flavonoid isolated from a Chinese medicinal plant Glycyrrhiza inflata, has antioxidant, anti-inflammatory and anti-cancer properties. Licochalcone D inhibit phosphorylation of NF-κB p65 in LPS signaling pathway. Licochalcone D inhibits JAK2, EGFR and Met (c-Met) activities and induces ROS-dependent apoptosis. Licochalcone D also induces caspases activation and poly (ADP-ribose) polymerase (PARP) cleavage.

Licochalcone D Chemical Structure

CAS: 144506-15-0

Purity & Quality Control

Batch: S689901 DMSO] 100 mg/mL] false] Ethanol] 20 mg/mL] false] Water] Insoluble] false Purity: 99.95%

99.95

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Signaling Pathway

NF-κB Signaling Pathway

Choose Selective NF-κB Inhibitors

Biological Activity

Description

Licochalcone D (Lico D, LCD, LD), a flavonoid isolated from a Chinese medicinal plant Glycyrrhiza inflata, has antioxidant, anti-inflammatory and anti-cancer properties. Licochalcone D inhibit phosphorylation of NF-κB p65 in LPS signaling pathway. Licochalcone D inhibits JAK2, EGFR and Met (c-Met) activities and induces ROS-dependent apoptosis. Licochalcone D also induces caspases activation and poly (ADP-ribose) polymerase (PARP) cleavage.

Targets

NF-κB ^[1]

JAK2 ^[2]

EGFR ^[3]

Met ^[3]

Caspase ^[3]

Click to View More Targets

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-05-22)
NCT06045416	Not yet recruiting	Lyme Disease\|Borrelia Infections	University Children''s Hospital Zurich\|Institute of Medical Microbiology University of Zurich Zurich Switzerland	April 1 2024	--
NCT06003179	Not yet recruiting	Lymphoma Large B-Cell Diffuse	University Health Network Toronto	April 2024	Phase 1
NCT06014762	Recruiting	Diffuse Large B Cell Lymphoma\|Follicular Lymphoma\|Mantle Cell Lymphoma\|Marginal Zone Lymphoma\|Primary Mediastinal Large B-cell Lymphoma (PMBCL)\|Chronic Lymphocytic Leukemia	Poseida Therapeutics Inc.\|Roche-Genentech	April 2024	Phase 1
NCT06358859	Not yet recruiting	Cardiometabolic Risk Factors\|Diabetes\|High Blood Pressure\|Obesity\|Nutrition Security	Tufts University\|National Institute on Minority Health and Health Disparities (NIMHD)\|Tougaloo College Mississippi\|Delta Health Center Mississippi\|Reuben V. Anderson Center for Justice at Tougaloo	April 2024	Not Applicable
NCT05559801	Not yet recruiting	Osteogenesis Imperfecta\|Osteogenesis Imperfecta Type III	Emory University	April 2024	Phase 1\|Phase 2

References

Chemical Information & Solubility

Molecular Weight	354.40	Formula	C₂₁H₂₂O₅
CAS No.	144506-15-0	SDF	--
Storage (From the date of receipt)	3 years -20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years -20°C powder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 100 mg/mL ( (282.16 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 20 mg/mL

Water : Insoluble

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In vivo
Batch:

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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