SPHK

SPHK Products

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  • SPHK Inhibitors (5)
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Catalog No. Product Name Information Product Use Citations Product Validations
S7177 PF-543 hydrochloride PF-543 hydrochloride, a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM, exhibits >100-fold selectivity over the SphK2 isoform. PF-543 hydrochloride induces apoptosis, necrosis, and autophagy.
J Transl Med, 2024, 22(1):43
Int J Mol Sci, 2023, 24(9)8303
Cell Res, 2022, 10.1038/s41422-022-00614-0
S7174 Opaganib (ABC294640) Opaganib (ABC294640) is an orally bioavailable and selective sphingosine kinase-2 (SphK2) inhibitor with IC50 of approximately 60 μM. Phase 1/2.
Cell Res, 2022, 10.1038/s41422-022-00614-0
Bioact Mater, 2022, 15:29-43
Clin Transl Med, 2022, 12(2):e695
S7176 SKI II SKI II (SphK-I2) is a highly selective and non ATP-competitive sphingosine kinase (SphK) inhibitor with IC50 of 0.5 μM, while exhibiting no inhibitory action on other kinases including PI3K, PKCα and ERK2.
Clin Transl Med, 2022, 12(2):e695
Int J Biol Sci, 2022, 18(7):2994-3005
Int J Biol Sci, 2022, 18(7):2994-3005
S0817 SKI-V SKI V is a noncompetitive and potent inhibitor of non-lipid sphingosine kinase with IC50 of 2 μM for GST-hSK. SKI-V also inhibits PI3K with IC50 of 6 μM for hPI3k. SKI-V decreases formation of the mitogenic second messenger sphingosine-1-phosphate (S1P) and induces apoptosis with antitumor activity.
Cell Death Discov, 2022, 8(1):48
Cell Death Discov, 2022, 8(1):48
S6512 Defensamide (MHP) Defensamide (MHP) is an activator of sphingosine kinase (SPHK1). It can modulate the innate epidermal immune response by potentiating SPHK1 activity and inducing cAMP production.
E1218 K6PC-5 K6PC-5, a ceramide derivative, is a sphingosine kinase 1 (SPHK1) activator and elicits a rapid transient increase in intracellular calcium levels.
Cell Prolif, 2024, e13604.
Int J Biol Sci, 2022, 18(7):2994-3005
S5989 SKI-178 SKI-178 is a potent inhibitors of sphingosine kinase-1 (SphK1) and SphK2 with IC50 values ranging from ∼500 nM to ∼1 μM depending on AML cell lines.
S7177 PF-543 hydrochloride PF-543 hydrochloride, a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM, exhibits >100-fold selectivity over the SphK2 isoform. PF-543 hydrochloride induces apoptosis, necrosis, and autophagy.
J Transl Med, 2024, 22(1):43
Int J Mol Sci, 2023, 24(9)8303
Cell Res, 2022, 10.1038/s41422-022-00614-0
S7174 Opaganib (ABC294640) Opaganib (ABC294640) is an orally bioavailable and selective sphingosine kinase-2 (SphK2) inhibitor with IC50 of approximately 60 μM. Phase 1/2.
Cell Res, 2022, 10.1038/s41422-022-00614-0
Bioact Mater, 2022, 15:29-43
Clin Transl Med, 2022, 12(2):e695
S7176 SKI II SKI II (SphK-I2) is a highly selective and non ATP-competitive sphingosine kinase (SphK) inhibitor with IC50 of 0.5 μM, while exhibiting no inhibitory action on other kinases including PI3K, PKCα and ERK2.
Clin Transl Med, 2022, 12(2):e695
Int J Biol Sci, 2022, 18(7):2994-3005
Int J Biol Sci, 2022, 18(7):2994-3005
S0817 SKI-V SKI V is a noncompetitive and potent inhibitor of non-lipid sphingosine kinase with IC50 of 2 μM for GST-hSK. SKI-V also inhibits PI3K with IC50 of 6 μM for hPI3k. SKI-V decreases formation of the mitogenic second messenger sphingosine-1-phosphate (S1P) and induces apoptosis with antitumor activity.
Cell Death Discov, 2022, 8(1):48
Cell Death Discov, 2022, 8(1):48
S5989 SKI-178 SKI-178 is a potent inhibitors of sphingosine kinase-1 (SphK1) and SphK2 with IC50 values ranging from ∼500 nM to ∼1 μM depending on AML cell lines.
S6512 Defensamide (MHP) Defensamide (MHP) is an activator of sphingosine kinase (SPHK1). It can modulate the innate epidermal immune response by potentiating SPHK1 activity and inducing cAMP production.
E1218 K6PC-5 K6PC-5, a ceramide derivative, is a sphingosine kinase 1 (SPHK1) activator and elicits a rapid transient increase in intracellular calcium levels.
Cell Prolif, 2024, e13604.
Int J Biol Sci, 2022, 18(7):2994-3005

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